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Inter-laboratory variability in mass spectrometry-based proteomics workflows

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WEGLER, Christine (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): Christine Wegler: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Cardiovascular Metabolic Diseases DMPK, AstraZeneca, Mölndal, Sweden
    Fabienne Z Gaugaz: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Tommy B Andersson: Cardiovascular Metabolic Diseases DMPK, AstraZeneca, Mölndal, Sweden
    Jacek R Wisniewski: Department of Proteomics and Signal Transduction, Biochemical Proteomics Group, Max Planck Institute of Biochemistry, Martinsried, Germany
    Stefan Oswald: Center of Drug Absorption and Transport, University Medicine of Greifswald, Greifswald, Germany
    Christian Gröer: Center of Drug Absorption and Transport, University Medicine of Greifswald, Greifswald, Germany
    Diana Busch: Center of Drug Absorption and Transport, University Medicine of Greifswald, Greifswald, Germany
    Frederik Weiss: NMI Natural and Medical Sciences Institut, University of Tuebingen, Tuebingen, Germany
    Helen Hammer: NMI Natural and Medical Sciences Institut, University of Tuebingen, Tuebingen, Germany
    Thomas O Joos: NMI Natural and Medical Sciences Institut, University of Tuebingen, Tuebingen, Germany
    Oliver Poetz: NMI Natural and Medical Sciences Institut, University of Tuebingen, Tuebingen, Germany
    Heleen Wortelboer: TNO, TNO, Zeist, Netherlands
    Evita van de Steeg: TNO, TNO, Zeist, Netherlands
    Brahim Achour: Manchester Pharmacy School, University of Manchester, Manchester, United Kingdom
    Amin Rostami-Hodjegan: Manchester Pharmacy School, University of Manchester, Manchester, United Kingdom
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Large variability in protein quantification by a plethora of proteomics workflows has been observed.

    Aims

    The aim was to find causes to variability in membrane protein quantification.

    Methods

    Membrane proteins essential for drug disposition (CYPs, UGTs, SLCs and ABCs) were quantified in ten human liver samples, by six mass

    ..

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Last update 4 October 2019

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