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Pharmacokinetics in zebrafish larvae: characterizing acetaminophen absorption and clearance in maturing larvae

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: VAN WIJK, Rob Christiaan (LACDR, Cluster Systems Pharmacology, Leiden, Netherlands)
  • Co-author(s): Rob C van Wijk: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
    Elke H J Krekels: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
    Vasudev Kantae: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
    Amy C Harms: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
    Yuanhao Guo: Imaging and BioInformatics, Leiden Institute of Advanced Computer Science (LIACS), Leiden, Netherlands
    Wouter J Veneman: Division of Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden, Netherlands
    Fons J Verbeek: Imaging and BioInformatics, Leiden Institute of Advanced Computer Science (LIACS), Leiden, Netherlands
    Thomas Hankemeier: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
    Herman P Spaink: Division of Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden, Netherlands
    Piet H van der Graaf: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands;QSP, Certara, Canterbury, United Kingdom
  • Abstract:

    Backgrounds

    Zebrafish larvae are increasingly used in drug discovery and development. Characterizing internal drug concentrations over time will improve interpretation of efficacy and toxicity data. Recently we developed a method to quantify drug pharmacokinetics in zebrafish larvae of 3 days post fertilization (dpf) using paracetamol (APAP).

    Aims

    To

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Last update 4 October 2019

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