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Effect of Obesity on the Transdermal Absorption of Fentanyl

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SAI, Yoshimichi (Kanazawa University, Department of Hospital Pharmacy, Kanazawa, Japan)
  • Co-author(s): Yoshimichi Sai: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Shintaro Gake: School of Pharmacy, Kanazawa University, Kanazawa, Japan
    Makiko Takabayashi: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Hiroko Sanada: School of Pharmacy, Kanazawa University, Kanazawa, Japan
    Yuriko Yoda: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Eriko Yasuda: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Yusuke Hara: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Tsutomu Shimada: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
    Ken-Ichi Miyamoto: Department of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan
  • Abstract:

    Backgrounds

    Fentanyl, a synthetic µ1-opioid subjected to significant metabolism by CYP3A, is clinically approved as transdermal patch. The dose should be titrated individually to a tolerable and adequate analgesia. But its intra-individual variation of the transdermal absorption has not been clarified yet.

    Aims

    We aimed to clarify effect of obesity

    ..

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Last update 4 October 2019

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