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A model-based comparison of absorption pharmacokinetics for a selective glucocorticoid receptor modulator administered with different inhalation devices

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SADIQ, Muhammad Waqas (AstraZeneca, Quantitative Clinical Pharmacology, Mölndal, Sweden)
  • Co-author(s): Muhammad Waqas Sadiq: Quantitative Clinical Pharmacology (ECD), AstraZeneca R&D, Gothenburg, Sweden
    Åsa Kragh: Quantitative Clinical Pharmacology (ECD), AstraZeneca R&D, Gothenburg, Sweden
    Susanne Prothon: Quantitative Clinical Pharmacology (ECD), AstraZeneca R&D, Gothenburg, Sweden
    Yingxue Chen: Quantitative Clinical Pharmacology (ECD), AstraZeneca R&D, Gothenburg, Sweden
    Ajay Aggarwal: Early Clinical development, AstraZeneca R&D, Waltham, United States
    Ulrika Wahlby-Hamren: Quantitative Clinical Pharmacology (ECD), AstraZeneca R&D, Gothenburg, Sweden
  • Abstract:

    Backgrounds

    AZD7594 is non-steroidal selective inhaled glucocorticoid receptor modulator (iSGRM) currently in development for the treatment of asthma. 

    Aims

    This work presents population pharmacokinetic (PK) modelling performed to quantify the absorption PK after inhaled administration of AZD7594 with different devices. 

    Methods

    Data from a phase 1

    ..

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Last update 4 October 2019

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