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Revisiting human tissue drug distribution: Limitations of current prediction models and potential impact of lipid contributions in fraction unbound

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MUSTHER, Helen (University of Manchester, Manchester, United Kingdom)
  • Co-author(s): Helen Musther: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom;, Simcyp Ltd (Certara), Sheffield, United Kingdom
    Avijit Ghosh: Janssen Pharmaceuticals, PA, United States
    Iain Gardner: Simcyp Ltd (Certara), Sheffield, United Kingdom
    Amin Rostami-Hodjegan: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom;, Simcyp Ltd (Certara), Sheffield, United Kingdom
    David Hallifax: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom
  • Abstract:

    Backgrounds

    Values of drug partitioning to tissue (Kp) are fundamental inputs to physiologically-based pharmacokinetic models. Since experimental determination in human presents practical and ethical challenges, models generally rely on predicted values. However, existing Kp prediction models have limitations which must be addressed to ensure their ..

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Last update 4 October 2019

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