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Validated LC-MS/MS method for determination of total and free daptomycin in human plasma and its clinical application

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MIYADERA, Yukari (Hamamatsu University School of Medicine, Department of Hospital Pharmacy, Hamamatsu, Japan)
  • Co-author(s): Yukari Miyadera: Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Takafumi Naito: Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Takahiro Yamada: Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Junichi Kawakami: Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Abstract:

    Backgrounds

    Daptomycin displays plasma protein binding as high as 90%. Few practical methods using a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the determination of free daptomycin (fDAP) in human plasma have not been published.

    Aims

    This study aimed to develop a validated LC-MS/MS method for determination of total

    ..

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Last update 4 October 2019

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