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Evaluation of transport of tyrosine kinase inhibitors across the blood-brain barrier in the pericyte-deficient state

  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • By: MIHAJLICA, Nebojsa (Uppsala University, Pharmaceutical Biosciences, Uppsala, Sweden)
  • Co-author(s): Nebojsa Mihajlica: Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Christer Betsholtz: Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Margareta Hammarlund-Udenaes: Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
  • Abstract:


    Pericytes play an important role in the maintenance of blood-brain barrier (BBB) transport properties. Tyrosine kinase inhibitors (TKIs) are drugs which have limited transport across the functional BBB, mainly due to active efflux processes.


    To evaluate the role of pericytes in BBB transport, by assessing several TKIs in a


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Last update 4 October 2019

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