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Effect of Hepatic and Renal Functions of Pharmacokinetics of Naproxen in Guinea Pigs: Acyl Glucuronide Concentration and Irreversible Binding to Plasma Protein

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: IWAKI, Masahiro (Kindai University, Faculty of Pharmacy, Higashi-Osaka, Japan)
  • Co-author(s): Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan
    Taro Ogiso: Department of Pharmacy, Kindai University, Osaka, Japan
    Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
    Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan
  • Abstract:

    Backgrounds

    Glucuronide metabolite of NSAIDs including naproxen (NA) forms covalent binding with proteins and triggers anaphylaxis. Glucuronide of NSAIDs is mostly generated at liver and kidney, and excreted in bile, urine and blood.

    Aims

    We aimed to determine effect of hepatic and renal dysfunctions on plasma concentrations of NA and its two major

    ..

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Last update 4 October 2019

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