Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Discovery of novel pharmacogenomic biomarkers for montelukast with massively parallel sequencing

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HIRVENSALO, Päivi (University of Helsinki, Helsinki, Finland)
  • Co-author(s): Päivi Hirvensalo: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Aleksi Tornio: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Mikko Neuvonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Tuija Tapaninen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Maria Paile-Hyvärinen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Vesa Kärjä: Department of Pathology, Kuopio University Hospital, Kuopio, Finland
    Ville Männistö: Department of Medicine, University of Eastern Finland, Kuopio, Finland
    Jussi Pihlajamäki: Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland
    Janne Backman: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Mikko Niemi: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • Abstract:

    Backgrounds

    Large interindividual variability exists in the pharmacokinetics and effects of montelukast.

    Aims

    Our aim was to investigate how sequence variations in pharmacokinetic genes affect the pharmacokinetics of montelukast and its metabolites.

    Methods

    A single 10 mg oral dose of montelukast was administered to 191 healthy volunteers. Montelukast

    ..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses