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A semi-mechanistic PK/PD model to elucidate levofloxacin-induced killing and resistance development of Escherichia coli

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: GOEBGEN, Eva (Institute of Pharmacy, Department of Clinical Pharmacy and Biochemistry, Berlin, Germany)
  • Co-author(s): Eva B. Goebgen: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
    Sebastian G. Wicha: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
    Charlotte Kloft: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
  • Abstract:

    Backgrounds

    Emerging resistance is known to be enhanced by misuse of antibiotics.

    Aims

    This project aimed at elucidating the bacterial killing of levofloxacin (LEV) against and the resistance development of Escherichia coli (E. coli) by semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modelling.

    Methods

    To describe in vitro data of resistant E

    ..

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Last update 4 October 2019

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