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Impact of renal transporters on paediatric renal clearance

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: CRISTEA, Sinziana (LACDR, Pharmacology, Leiden, Netherlands)
  • Co-author(s): Sinziana Cristea: Pharmacology, LACDR, Leiden University, Leiden, Netherlands
    Elke H. J. Krekels: Pharmacology, LACDR, Leiden University, Leiden, Netherlands
    Elisa A. M. Calvier: Pharmacology, LACDR, Leiden University, Leiden, Netherlands
    Catherijne A. J. Knibbe: Pharmacology, LACDR, Leiden University, Leiden, Netherlands;Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, Netherlands
  • Abstract:

    Backgrounds

    Transporters hold a key role in drug disposition, however, their impact on renal clearance (CLR) has been less studied, particularly in children (Brouwer 2015).

    Aims

    Using physiology-based simulations we investigate the impact of transporters activity (CLs,int) and their ontogeny (TO) on CLR.

    Methods

    Using R, we generated virtual paediatric

    ..

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Last update 4 October 2019

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