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BDDCS Classification Does Not Support BSEP Inhibition As Being DILI Causative

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: CHAN, Rosa (University of California San Francisco, Bioengineering and Therapeutic Sciences, San Francisco, United States)
  • Co-author(s): Rosa Chan: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
    Leslie Benet: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  • Abstract:

    Backgrounds

    Drug-induced liver injury (DILI) is a leading cause of drug failure and a major reason for drug withdrawals from the market. Some primary compound-specific mechanisms linked to DILI include: cytotoxicity, reactive metabolite formation, inhibition of the bile salt export pump (BSEP), and mitochondrial dysfunction. 

    Aims

    The present study

    ..

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Last update 4 October 2019

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