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The Effect of Protein Binding on the Interaction Between Transporters and Highly Protein Bound Drugs

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BOWMAN, Christine (San Francisco, United States)
  • Co-author(s): Christine Bowman: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
    Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
    Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
  • Abstract:

    Backgrounds

    Accurately predicting hepatic clearance from in vitro results is crucial in the selection process of new molecular entities for clinical development.  However, current in vitro-in vivo extrapolation methods often lead to underprediction, particularly for compounds that are highly protein bound and substrates for uptake transporters.

    Aims

    T

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Last update 4 October 2019

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