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The influence of sertraline on the pharmacokinetics of carvedilol. A preclinical study in rats

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ABRUDAN, Maria Bianca ("Iuliu Hatieganu" University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj Napoca, Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania)
  • Co-author(s): Maria Bianca Abrudan: Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj Napoca, Romania
    Dana Maria Muntean: Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania
    Maria Adriana Neag: Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania
    Laurian Vlase: Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania
    Ana-Maria Gheldiu: Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania
  • Abstract:

    Backgrounds

    Carvedilol is a nonselective β-blocking agent, which is commonly used for the treatment of different cardiovascular diseases. Carvedilol is metabolized via cytochrome P450, CYP2D6 isoform. Sertraline is an antidepressant known to have inhibitory effect on cytochrome P450 2D6.

    Aims

    The objective of this study was to investigate the effect

    ..

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Last update 4 October 2019

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