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Discovery of novel thiohydantoin derived AR antagonists: design, synthesis and biological evaluation

  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • By: ZHANG, Daoguang (Shandong University, Department of Medicinal Chemistry, Jinan, China)
  • Co-author(s): Daoguang Zhang: Department of Medicinal Chemistry, Shandong University, Jinan, China
    Solomon Asnake: The Life Science Center, Örebro University, Örebro, Sweden
    Per-Erik Olsson: The Life Science Center, Örebro University, Örebro, Sweden
    Guisen Zhao: Department of Medicinal Chemistry, Shandong University, Jinan, China
  • Abstract:

    Backgrounds

    Prostate cancer (PCa) is the most frequently diagnosed male cancer in western societies. Androgen receptor (AR) signaling provides the main driving force for the development of PCa, even for castration resistant PCa (CRPC), making AR a critical therapeutic target for the treatment of PCa.

    Aims

    Enzalutamide (MDV3100), approved in 2012 by

    ..

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Last update 4 October 2019

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