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Synthetic studies toward a quinolinone alkaloid aspoquinolone A possessing potent antiproliferative activity

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TSUBUKI, Masayoshi (Hoshi University, Tokyo, Japan)
  • Co-author(s): Masayoshi Tsubuki: Hoshi University, Tokyo, Japan
    Takumi Hosozawa: Rikkyo University, Tokyo, Japan
    Hiromasa Yokoe: Hoshi University, Tokyo, Japan
    Hiroaki Tokiwa: Rikkyo University, Tokyo, Japan
  • Abstract:

    Backgrounds

    Recently, aspoquinolone A (1), a quinolinone alkaloid, has been isolated from Aspergillus nidulans (HKI 0410) by Hertweck et al. and exhibits high cytotoxicity against L-929 mouse fibroblast cell lines (GI50 10.6 μg ml-1) and good antiproliferative effects on human leukemia cell line K-562 (GI50 17.8 μg ml-1). The structural features of ..

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Last update 4 October 2019

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