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Influence of lipophilicity and hydrogen bond formation on passive diffusion of small-molecule drugs across hexadecane-based artificial cell membranes

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: THORMANN, Ursula (Uppsala University, Pharmacy, Uppsala, Sweden)
  • Co-author(s): Ursula Thormann: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Bradley Doak: Department of Chemistry, Uppsala University, Uppsala, Sweden;Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
    Per Larsson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Matteo Rossi Sebastiano: Department of Chemistry, Uppsala University, Uppsala, Sweden
    Maria Backlund: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Science for Life Laboratory, Uppsala, Sweden
    Georgios Imanidis: Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Jan Kihlberg: Department of Chemistry, Uppsala University, Uppsala, Sweden
    Pär Matsson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Intramolecular hydrogen bond (IMHB) formation has been suggested as a valuable tool to increase drug permeability.

    Aims

    The aim was to assess the impact of IMHB and other molecular properties on small-molecule diffusion across hexadecane membranes.

    Methods

    A hexadecane-based artificial membrane assay (HDM-PAMPA) was developed to mimic the

    ..

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Last update 4 October 2019

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