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Plectranthus diterpenes as a potential anticancer and antitubercular combined system

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SILVA, Henrique (CBIOS/ULHT, Lisboa, Portugal)
  • Co-author(s): Catarina Garcia: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Joana Marçalo: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Henrique Silva: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Marisa Nicolai: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Epole Ntungwe: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Catarina Silva: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Milica Pesik: Institute for Biological Research, “Siniša Stanković“, University of Belgrade, Belgrade, Serbia
    Tijana Stankovic: Institute for Biological Research, “Siniša Stanković“, University of Belgrade, Belgrade, Serbia
    Catarina Reis: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Gian Maria Fimia: Laboratorio di Biologia Cellulare e Microscopia Elettronica, National Institute for the Infectious Disease Lazzaro Spallanzani, Rome, Italy
    Célia Faustino: iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal
    Carlos A. M. Afonso: iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal
    Luís M. Rodrigues: CBIOS, Universidade Lusófona, Lisboa, Portugal
    Patrícia Rijo: CBIOS, Universidade Lusófona, Lisboa, Portugal;iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal
  • Abstract:

    Backgrounds

    Medicinal plants such as Plectranthus spp. represent a source of lead natural products. Previously, some halimane derivatives (P. ornatus Benth.), structurally similar to Rv3377c and Rv3378c targets (important to Mycobacterium tuberculosis survival and virulence) were prepared and the cytotoxic agent 6,7-dehydroroyleanone  was isolated

    ..

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Last update 4 October 2019

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