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Rational design of new azole compounds and their potent inhibitory effects on fungal growth

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SARI, Suat (Ankara, Turkey)
  • Co-author(s): Suat Sari: Department of Pharmaceutical Chemistry, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
    Didem Kart: Department of Pharmaceutical Microbiology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
    Arzu Karakurt: Department of Pharmaceutical Chemistry, Inonu University Faculty of Pharmacy, Malatya, Turkey
    Selma Saraç: Department of Pharmaceutical Chemistry, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
    Sebnem G. Essiz: Bioinformatics and Genetics Department, Kadir Has University Faculty of Engineering and Natural Sciences, Istanbul, Turkey
    Sevim Dalkara: Department of Pharmaceutical Chemistry, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
  • Abstract:

    Backgrounds

    Invasive candidiasis is a serious health threat for immune-compromised patients. Candida albicans is the most common species, yet non-albicans Candida (naC) infections with high mortality and drug resistance have been reported. Azole antifungals, which target fungal lanosterol 14 α-demethylase (CYP51), are a class of choice in invasive

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Last update 4 October 2019

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