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Characteristic pH-profiles of passive membrane permeability for chemical classes

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: OJA, Mare (University of Tartu, Institute of Chemistry, Tartu, Estonia)
  • Co-author(s): Mare Oja: Institute of Chemistry, University of Tartu, Tartu, Estonia
    Uko Maran: Institute of Chemistry, University of Tartu, Tartu, Estonia
  • Abstract:

    Backgrounds

    Approved drugs include approximately 35% bases, 20% acids, 30% ampholytes and 15% neutrals. The properties of ionisable compounds are highly influenced by the pH of the environment. The pH range in gastrointestinal tract is from ~2 to ~9. Commonly absorption related properties, permeability and solubility, for drug candidates is..

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Last update 4 October 2019

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