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Synthesis and acute toxicity assesment of new pyrazolinone derivatives as antivirulence agents

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NITULESCU, George Mihai (“Carol Davila” University of Medicine and Pharmacy, Pharmaceutical Chemistry, Faculty of Pharmacy, Bucharest, Romania)
  • Co-author(s): Georgiana Nitulescu: Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    Octavian Tudorel Olaru: Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    George Mihai Nitulescu: Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Abstract:

    Backgrounds

    The emergence of antibiotic-resistant bacteria is a major health concern due to therapeutic failure of many drugs currently in use against pathogenic microbes. Sortases are transpeptidases that occur in almost all Gram-positive bacteria and playing a very important role in virulence and infection.

    Aims

     We designed new pyrazolinone

    ..

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Last update 4 October 2019

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