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Design, synthesis and biological evaluation of imidazole derivatives as novel atypical selective cyclooxygenase-2 inhibitors.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: KIANI, Azin (Shahid Beheshti University of Medical Sciences, pharmaceutical chemistry, Sari, Iran, Islamic Republic Of)
  • Co-author(s): Azin Kiani: Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic Of
    Elham Rezaee: Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic Of
    Sayyed Abbas Tabatabai: Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic Of
  • Abstract:

    Backgrounds

    Nonsteroidal anti-inflammatory drugs block cyclooxygenase isoenzymes (COX-1 and COX-2) and their long term use leads to a number of adverse effects related to normal physiological expression of COX-1, therefore the development of selective COX-2 inhibitors was prompted.

    Aims

    Here a new structure-activity relationship for selective COX-2

    ..

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Last update 4 October 2019

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