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Transcarbamoylation of sulfonyl carbamates to generate new angiotensin II type 2 receptor (AT2R) ligands

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ISAKSSON, Rebecka (Uppsala University, Department of Medicinal Chemistry, Uppsala, Sweden)
  • Co-author(s): Johan Wannberg: Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
    Rebecka Isaksson: Division of Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
    Mathias Hallberg: Beijer Laboratory, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Mats Larhed: Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    The renin-angiotensin system (RAS) is well-known for its role in blood-pressure regulation and fluid/electrolyte balance. This effect is mediated via the GPCR, angiotensin II type 1 receptor (AT1R). The endogenous ligand of this receptor, AngII, also binds to the GPCR angiotensin II type 2 receptor (AT2R). The function of AT2R has long..

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Last update 4 October 2019

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