Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Fragment-based Discovery of Allosteric Modulators on Metabotropic Glutamate Receptor 5

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BIAN, Yuemin (University of Pittsburgh, School of Pharmacy, Pittsburgh, United States)
  • Co-author(s): Yuemin Bian: School of Pharmacy, University of Pittsburgh, Pittsburgh, United States;Drug Discovery Institute, University of Pittsburgh, Pittsburgh, United States;NIH National Center of Excellence for Computational Drug Abuse Research, National Institution of Health, Pittsburgh, United States
    Zhiwei Feng: School of Pharmacy, University of Pittsburgh, Pittsburgh, United States;Drug Discovery Institute, University of Pittsburgh, Pittsburgh, United States;NIH National Center of Excellence for Computational Drug Abuse Research, National Institution of Health, Pittsburgh, United States
    Peng Yang: School of Pharmacy, University of Pittsburgh, Pittsburgh, United States;Drug Discovery Institute, University of Pittsburgh, Pittsburgh, United States;NIH National Center of Excellence for Computational Drug Abuse Research, National Institution of Health, Pittsburgh, United States
    Xiang-Qun Xie: School of Pharmacy, University of Pittsburgh, Pittsburgh, United States;NIH National Center of Excellence for Computational Drug Abuse Research, National Institution of Health, Pittsburgh, United States;Drug Discovery Institute, University of Pittsburgh, Pittsburgh, United States;Department of Computational Biology and Structural Biology, University of Pittsburgh, Pittsburgh, United States
  • Abstract:

    Backgrounds

    Allosteric modulators exhibit significant advantages against the corresponding orthosteric ligands, including better physicochemical properties, improved selectivity, and reduced risk of over-sensitization towards their receptors. mGlu5, a member of class C GPCRs, has been considered a promising therapeutic target for treating many CNS..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses