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Sulfasalazine-induced agranulocytosis is associated with the human leukocyte antigen locus

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: WADELIUS, Mia (Uppsala University, Medical Sciences, Clinical Pharmacology, Uppsala, Sweden)
  • Co-author(s): Mia Wadelius: Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala , Sweden
    Niclas Eriksson: Medical Sciences, Uppsala University, Uppsala, Sweden;Uppsala Clinical Research Center, Uppsala Region, Uppsala, Sweden
    Reinhold Kreutz: Charité - Universitätsmedizin Berlin, Institut für Klinische Pharmakologie und Toxikologie, Berlin, Germany
    Emmanuelle Bondon-Guitton: Service de Pharmacologie Médicale et Clinique, Faculté de Médecine de l'Université de Toulouse, Toulouse, France
    Luisa Ibañez: Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    Alfonso Carvajal: Centro de Estudios sobre la Seguridad de los Medicamentos, Universidad de Valladolid, Valladolid, Spain
    M. Isabel Lucena: Instituto de Investigación Biomédica de Málaga, University of Málaga, Málaga, Spain
    Esther Sancho Ponce: Servei d'Hematologia i Banc de Sang, Hospital General de Catalunya, Sant Cugat del Vallès, Spain
    Mariam Molokhia: NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation, King's College London, London, United Kingdom
    Javier Martin: Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada, Spain
    Tomas Axelsson: Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala , Sweden
    Hugo Kohnke: Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala , Sweden
    Qun-Ying Yue: Medical Products Agency, Swedish State Authority, Uppsala, Sweden
    Patrik K. E. Magnusson: Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Mats Bengtsson: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Pär Hallberg: Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala , Sweden
  • Abstract:

    Backgrounds

    Agranulocytosis is a serious rare adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. The reaction is believed to be immune-mediated, but risk factors are unknown.

     

    Aims

    The European Drug-induced Agranulocytosis Consortium (EUDAC) aimed to find genetic risk factors for

    ..

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Last update 4 October 2019

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