The impact of inflammation and organ failure on CYP3A-mediated midazolam metabolism in critically ill children: predictive performance and extrapolation of a pediatric pharmacokinetic model

• In: Short Communications E1 on Monday, 22 May 2017, 13:30-15:00
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: BRUSSEE, Janneke (Leiden University, LACDR/Pharmacology, Leiden, Netherlands)
• Co-author(s): Janneke M Brussee: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands
  Nienke J Vet: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
  Elke H J Krekels: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands
  Abraham J Valkenburg: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
  Evelyne Jacqz-Aigrain: Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France
  Joop M A van Gerven: Centre for Human Drug Research, Leiden, Netherlands
  Johannes N van den Anker: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands;Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, Basel, Switzerland;Division of Clinical Pharmacology, Children’s National Health System, Washington, DC, United States
  Dick Tibboel: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
  Matthijs de Hoog: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
  Saskia N de Wildt: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands;Department of Pharmacology and Toxicology, Radboud University Medical Centre, Nijmegen, Netherlands
  Catherijne A J Knibbe: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands;Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, Netherlands
  
• Abstract:

  Backgrounds

  Recently, the impact of inflammation and organ failure on the reduction in cytochrome P450 (CYP) 3A-mediated clearance of midazolam in critically ill children has been quantified [Vet NJ et al. Am J Respir Crit Care Med. 2016 Jul 1;194(1):58-66].

  Aims

  Our aim is to evaluate the predictive performance of this population pharmacokinetic
  ..

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