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The impact of inflammation and organ failure on CYP3A-mediated midazolam metabolism in critically ill children: predictive performance and extrapolation of a pediatric pharmacokinetic model

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: BRUSSEE, Janneke (Leiden University, LACDR/Pharmacology, Leiden, Netherlands)
  • Co-author(s): Janneke M Brussee: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands
    Nienke J Vet: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
    Elke H J Krekels: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands
    Abraham J Valkenburg: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
    Evelyne Jacqz-Aigrain: Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France
    Joop M A van Gerven: Centre for Human Drug Research, Leiden, Netherlands
    Johannes N van den Anker: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands;Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, Basel, Switzerland;Division of Clinical Pharmacology, Children’s National Health System, Washington, DC, United States
    Dick Tibboel: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
    Matthijs de Hoog: Department of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands
    Saskia N de Wildt: Department of Pediatric Surgery, Erasmus MC - Sophia Children’s Hospital, Rotterdam, Netherlands;Department of Pharmacology and Toxicology, Radboud University Medical Centre, Nijmegen, Netherlands
    Catherijne A J Knibbe: Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands;Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, Netherlands
  • Abstract:

    Backgrounds

    Recently, the impact of inflammation and organ failure on the reduction in cytochrome P450 (CYP) 3A-mediated clearance of midazolam in critically ill children has been quantified [Vet NJ et al. Am J Respir Crit Care Med. 2016 Jul 1;194(1):58-66].

    Aims

    Our aim is to evaluate the predictive performance of this population pharmacokinetic

    ..

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Last update 4 October 2019

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