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A quality-by-design approach for highly systematic optimization of lipid-polymer hybrid nanoparticles toward efficient and safe intracellular delivery of siRNA cargo

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: THANKI, Kaushik (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
  • Co-author(s): Kaushik Thanki: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Xianghui Zeng: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Sarah Justesen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark;Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Sarah Tejlmann: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Emily Falkenberg: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Hanne Mørck Nielsen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Henrik Franzyk: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Camilla Foged: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  • Abstract:

    Backgrounds

    RNA interference therapy is highly target-specific and is mediated by small interfering RNA (siRNA).

    Aims

    The aim of the study was to apply a quality-by-design approach for the systematic optimization of siRNA-loaded lipid-polymer hybrid nanoparticles (LPNs) composed of lipid-like materials (lipidoids) and poly(DL-lactide-co-glycolide

    ..

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Last update 4 October 2019

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