Investigation of hydrophobic amino acids against moisture on in vitro aerosolization performance of highly hygroscopic spray-dried powders
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: YU, Jiaqi (The University of Sydney, Faculty of Pharmacy, Sydney, Australia)
- Co-author(s): Jiaqi Yu: Faculty of Pharmacy, The University of Sydney, Sydney, Australia
Thomas Gengenbach: CSIRO Manufacturing, Melbourne, Australia
John Denman: Future Industries Institute, University of South Australia, Adelaide, Australia
Hak-Kim Chan: Faculty of Pharmacy, The University of Sydney, Sydney, Australia
Amorphous drugs or excipients may absorb atmospheric moisture, causing powder aggregation and recrystallization. The resulting agglomerates or crystals with changed size and shape would adversely affect the powder dispersion and lung deposition.
To study the effect of hydrophobic amino acids on moisture protection to.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.