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Surface adhesion of pharmaceutical powders in relation to tableting performance

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: BADAL TEJEDOR, Maria (SP, Stockholm, Sweden)
  • Co-author(s): Maria Badal Tejedor: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden;Surface and Corrosion Science, KTH, Royal Intitute of Technology, Stockholm, Sweden
    Niklas Nordgren: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
    Michael Schuleit: Novartis Intitutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
    Anna Millqvist-Fureby: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
    Mark Rutland: Surface and Corrosion Science, KTH, Royal Intitute of Technology, Stockholm, Sweden;Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
  • Abstract:

    Backgrounds

    Problems associated to the adhesion of the powders to the tableting tools during tablet compaction are common. This is known as sticking and it remains poorly understood.

    Aims

    Analytical method development with atomic force microscopy (AFM) to characterize the mechanical and adhesive properties of the pharmaceutical powders.

    Methods

    ..

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Last update 4 October 2019

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