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In Vitro Cytotoxicity and In Vivo Biodistribution of Simvastatin-loaded Lecithin/Chitosan Nanoparticles: Nasal Region as an Appealing Route for Brain Delivery

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: CLEMENTINO, Adryana (University of Parma, Department of Pharmacy, Parma, Italy)
  • Co-author(s): Adryana Clementino: Department of Pharmacy, University of Parma, Parma, Italy;Science without Borders, National Council for Scientific and Technological Development, Brasilia, Brazil
    Michele Pozzoli: Graduate School of Health-Pharmacy, University of Technology Sydney, NSW, Australia
    Sergio Souza: Department of Radiology, Federal Universityof Rio de Janeiro, Rio de Janeiro, Brazil
    Fabio Sonvico: Department of Pharmacy, University of Parma, Parma, Italy
  • Abstract:


    Statins have been strongly advocated as potentially useful drugs for the prevention and treatment of neurodegenerative diseases. However, past clinical trials provided inconclusive results likely because of statins high hepatic metabolism and low permeability across the blood brain barrier.


    The aim of this work was to develop


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Last update 4 October 2019

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