In Vitro Cytotoxicity and In Vivo Biodistribution of Simvastatin-loaded Lecithin/Chitosan Nanoparticles: Nasal Region as an Appealing Route for Brain Delivery
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: CLEMENTINO, Adryana (University of Parma, Department of Pharmacy, Parma, Italy)
- Co-author(s): Adryana Clementino: Department of Pharmacy, University of Parma, Parma, Italy;Science without Borders, National Council for Scientific and Technological Development, Brasilia, Brazil
Michele Pozzoli: Graduate School of Health-Pharmacy, University of Technology Sydney, NSW, Australia
Sergio Souza: Department of Radiology, Federal Universityof Rio de Janeiro, Rio de Janeiro, Brazil
Fabio Sonvico: Department of Pharmacy, University of Parma, Parma, Italy
Statins have been strongly advocated as potentially useful drugs for the prevention and treatment of neurodegenerative diseases. However, past clinical trials provided inconclusive results likely because of statins high hepatic metabolism and low permeability across the blood brain barrier.
The aim of this work was to develop.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.