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PEGylation relieves lipid nanoparticle-induced neuroinflammatory response in mouse brain and enhanced brain delivery for targeting ischemia

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: LU, Yingmei (Zhejiang University City College, Hangzhou, China)
  • Co-author(s): Yingmei Lu: School of Medicine, Zhejiang University City College, HangZhou, China
    Nannan Lu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Dongmei Gong: School of Medicine, Zhejiang University City College, HangZhou, China
    Yixuan Yin: School of Medicine, Zhejiang University City College, HangZhou, China
    Tiantian Cui: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Xing Lv: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Yue Pan: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Yijie Liu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Fangying Yu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Feng Han: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  • Abstract:

    Backgrounds

    The host immune response as well as neurotoxicity of nanoparticle is an impediment to clinical translation. The evidences regarding stability and safety of nanoparticles is still lacking.

    Aims

    Reduce the nanoparticle-induced neuroinflammatory response and create a novel nanoparticle, which have a great promise for use in therapies

    ..

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Last update 4 October 2019

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