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Targeting TRPM2 Signaling to Relieve Brain Pericyte Injury

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: LU, Yingmei (Zhejiang University City College, Hangzhou, China)
  • Co-author(s): Lingxiao Shao: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Quan Jiang: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Ninghe Sun: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Danyang Chen: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Xiuxiu Liu: School of Medicine, Zhejiang University City College, HangZhou, China
    Yue Pan: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Yijie Liu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Fangying Yu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
    Feng Han: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  • Abstract:

    Backgrounds

    Dysfunction of neurovascular pericytes underlies the breakdown of the blood-brain barrier, but the molecular mechanisms are largely unknown.

    Aims

    In this study, we evaluated the role of the TRPM2 (transient receptor potential melastatin-related 2) channel and autophagy during brain pericyte injury in vitro and in vivo.

    Methods

    Moni

    ..

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Last update 4 October 2019

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