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Blood-brain barrier transport of docosahexaenoic acid and expression of fatty acid binding protein 5 are decreased in Alzheimer’s disease

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: NICOLAZZO, Joseph (Monash University, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
  • Co-author(s): Joseph Nicolazzo: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Yijun Pan: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Jennifer Short: Drug Discovery Biology, Monash University, Parkville, Australia
    Martin Scanlon: Medicinal Chemistry, Monash University, Parkville, Australia
    Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  • Abstract:

    Backgrounds

    Fatty acid binding protein 5 (FABP5) is a cytoplasmic protein which regulates the blood-brain barrier (BBB) transport of docosahexaenoic acid (DHA). DHA is an essential polyunsaturated fatty acid required for cognitive function and its brain levels are decreased in Alzheimer’s disease (AD).

    Aims

    To identify whether FABP5 deficiency leads

    ..

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Last update 4 October 2019

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