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Revealing multiple biochemical response patterns of remoxipride by integrating pharmacometabolomics and pharmacokinetic/pharmacodynamic modeling

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: VAN DEN BRINK, Willem (Leiden Academic Centre for Drug Research, Pharmacology, Leiden, Netherlands)
  • Co-author(s): Willem Van Den Brink: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Jeroen Elassais-Schaap: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Belén Gonzalez: Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Amy Harms: Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Piet Hein van der Graaf: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands;QSP, Certara, Canterbury, United Kingdom
    T Hankemeier: Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Elizabeth de Lange: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
  • Abstract:

    Backgrounds

    The use of mathematical models is key to improve the success rates of central nervous system (CNS) drug development. Whereas the prediction of the brain pharmacokinetics (PK) has become within reach (Yamamoto, Pharm Res, 2016), the prediction of the pharmacodynamics (PD) of CNS drugs is still a challenge. We need to gain insights into

    ..

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Last update 4 October 2019

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