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Evaluation of DILI Predictive Hypotheses in Early Drug Development

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: CHAN, Rosa (University of California San Francisco, Bioengineering and Therapeutic Sciences, San Francisco, United States)
  • Co-author(s): Rosa Chan: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
    Leslie Benet: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  • Abstract:

    Backgrounds

     

    Drug-induced liver injury (DILI) is a leading cause of drug failure in clinical trials and a major reason for drug withdrawals from the market. Idiosyncratic DILI has been shown to be dependent on both daily dose and extent of hepatic metabolism. Yet, early in drug development daily dose is unknown.

    Aims

     

    Here, we

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Last update 4 October 2019

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