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Optimization of drug delivery to tissues and avoiding drug induced phospholipidosis

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: LORYAN, Irena (Uppsala University, Pharmaceutical Biosciences, Uppsla, Sweden)
  • Co-author(s): Irena Loryan: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden
    Edmund Hoppe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Klaus Hansen: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Achim Kless: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Klaus Linz: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Virginia Marossek: Bayer Pharma, Wuppertal, Germany
    Bert Nolte: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Paul Ratcliffe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Derek Saunders: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Rolf Terlinden: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Anita Wegert: Mercachem, Nijmegen, Netherlands
    Andre Welbers: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Olaf Will: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Margareta Hammarlund-Udenaes: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden
  • Abstract:

    Backgrounds

    Understanding of the pharmacokinetic basis of drug-induced phospholipidosis (PLD) is limited.

    Aims

    We present a systematic approach to optimize drug delivery to tissues and to provide insight into tissue-specific PLD by evaluation of unbound intracellular and intralysosomal concentrations.

    Methods

    Intra-tissue distribution of the two

    ..

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Last update 4 October 2019

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