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A comparison of two different self immolative linker strategies in the design of lymph directing, triglyceride mimetic prodrugs of buprenorphine

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: HAN, Sifei (Monash University, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
  • Co-author(s): Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Tim Quach: Medicinal Chemistry, Monash University, Parkville, Australia
    Shea Lim: Medicinal Chemistry, Monash University, Parkville, Australia
    Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Jamie Simpson: Medicinal Chemistry, Monash University, Parkville, Australia
    Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  • Abstract:

    Backgrounds

    The oral bioavailability of buprenorphine (BUP) is limited by hepatic first-pass metabolism. Exploiting drug transport through the lymphatic system provides a means to circumvent first pass metabolism, since the intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Previous studies have

    ..

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Last update 4 October 2019

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