Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Valproic Acid Showed Antitumor Activity through Nuclear KIT-NFKBIB-NFKB Feedback in Imatinib-Resistant Gastrointestinal Stromal Tumors

  • At: 2016 FIP Congress in Buenos Aires (Argentina)
  • Type: Poster
  • By: HSUEH, Yuan-Shuo (National Health Research Institutes, National Institute of Cancer Research, Tainan, China Taiwan)
  • Co-author(s): Yuan-Shuo Hsueh:National Institute of Cancer Research,National Health Research Institutes,Tainan,Taiwan, Province of China|Hui Hua Chang:Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine,National Cheng Kung University,Tainan,Taiwan, Province of China|Chien-Feng Li:Department of Pathology,Chi-Mei Foundation Medical Center,Tainan,Taiwan, Province of China;National Institute of Cancer Research,National Health Research Institutes,Tainan,Taiwan, Province of China;Department of Biotechnology,Southern Taiwan University of Science and Technology,Tainan,Taiwan, Province of China|Yan-Shen Shan:Institute of Clinical Medicine, College of Medicine,National Cheng Kung University,Tainan,Taiwan, Province of China;Department of Surgery,National Cheng Kung University Hospital,Tainan,Taiwan, Province of China|Jonathan A Fletcher:Department of Pathology,Brigham and Women’s Hospital and Harvard Medical School,Boston,United States|Li-Tzong Chen:National Institute of Cancer Research,National Health Research Institutes,Tainan,Taiwan, Province of China;Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine,National Cheng Kung University,Tainan,Taiwan, Province of China;Department of Internal Medicine,National Cheng Kung University Hospital,Tainan,Taiwan, Province of China;Department of Internal Medicine,Kaohsiung Medical University Hospital, Kaohsiung,Taiwan, Province of China
  • Abstract:

    Gastrointestinal stromal tumor (GIST) is a dominantly mutant KIT-driven tumor. Drug resistance is an increasing clinical issue after long-term treatment. 

    In this study, two imatinib-resistant GIST cell lines, GIST48 and GIST430, were used as a model.

    Herein, we first showed that KIT is distributed both in the cytoplasm and nucleus in GIST cells.

    ..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses