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Hypnosis of Propofol is altered by coronary artery bypass grafting in surgical patients as a consequence of reduction on drug plasma protein binding

  • At: 2016 FIP Congress in Buenos Aires (Argentina)
  • Type: Presentation
  • By: SANTOS, Silvia (University of Sao Paulo, School of Pharmaceutical Science, Sao Paulo, Brazil)
  • Co-author(s): Silvia Regina Cavani Jorge Santos:|Carlos Roberto da Silva Filho:,University of Sao Paulo,|Cristina Sanches-Giraud:,Federal University of Sao Joao Del Rei,Divinopolis,|Carlindo Vieira Silva Jr.:,University of Sao Paulo,|Ricardo Antonio G. Barbosa:,University of Sao Paulo,|Luiz M.s. Malbouisson:Hospital das Clinicas,University of Sao Paulo,|Maria Jose Carvalho Carmona:,University of Sao Paulo,
  • Abstract:

    It is well known that cardiopulmonary bypass alters propofol kinetic disposition. 

     

    Ten patients (9M/1F) were included, 62 yrs; 75kg; 28kg/m2; 278min length of surgery. General anesthesia including sufentanil (0.5μg.kg-1.h-1), pancuronium (0.1 mg/kg) and propofol was infused to achieve the predicted plasma concentration of 2.0μg/mL during CABG and

    ..

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Last update 4 October 2019

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