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A new method for preparation of insulin-loaded poly(d,l-lactic-coglycolic acid) microspheres: release and stability study of protein

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: EMAMI, Jaber (Isfahan University of Medical Sciences, Isfahan, Iran)
  • Co-author(s): Rouholamini, Abdolhossien (Tehran University of Medical Sciences, TEHRAN, Iran)
    Gilani, Kambiz (Tehran University of Medical Sciences, TEHRAN, Iran)
    Nokhodchi, Ali (, The Universities of Kent and Greenwich, KENT, United Kingdom)
    Minaiyan, Mohsen (Isfahan University of Medical Sciences, ISFAHAN, Iran)
    Mahdavi, Hamid (Iran Polymer and Petrochemical Institute, TEHRAN, Iran)
    Hamishehkar, Hamed (Isfahan University of Medical Sciences, ISFAHAN, Iran)
  • Abstract:

    In order to increase the encapsulation efficiency of water soluble drugs, such as proteins and peptides, and to optimize the release profiles, an oil-in-oil (o/o) single emulsification method was developed. Poly(D,L-lactic-coglycolic acid) (PLGA) and insulin were dissolved in acetonitrile-water system at ratio of 5:1, v/v. This solution is then..

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Last update 4 October 2019

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