Effects of berberine on the transport of p-gp substrates across caco-2 and l-mdr1 cell monolayers

• At: Beijing (China) (2007)
• Type: Poster
• By: XIN, Huawen (Wuhan General Hospital, Wuhan, China)
• Co-author(s): Wu, Xiao-Chun (Wuhan General Hospital, WUHAN, China)
  Li, Qing (Wuhan General Hospital, WUHAN, China)
  Yu, Ai-Rong (Wuhan General Hospital, WUHAN, China)
  
• Abstract:

  AIM To investigate the effects of berberine (BBR) on the transport of P-gp substrates including cyclosporine A (CsA) and digoxin across Caco-2 and L-MDR cell monolayers. METHODS Permeability coefficients and transport rates of digoxin and CsA across Caco-2 and L-MDR1 monolayers were measured in the presence of BBR(50µM-5mM). RESULTS The..

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