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Effects of berberine on the transport of p-gp substrates across caco-2 and l-mdr1 cell monolayers

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: XIN, Huawen (Wuhan General Hospital, Wuhan, China)
  • Co-author(s): Wu, Xiao-Chun (Wuhan General Hospital, WUHAN, China)
    Li, Qing (Wuhan General Hospital, WUHAN, China)
    Yu, Ai-Rong (Wuhan General Hospital, WUHAN, China)
  • Abstract:

    AIM To investigate the effects of berberine (BBR) on the transport of P-gp substrates including cyclosporine A (CsA) and digoxin across Caco-2 and L-MDR cell monolayers. METHODS Permeability coefficients and transport rates of digoxin and CsA across Caco-2 and L-MDR1 monolayers were measured in the presence of BBR(50µM-5mM). RESULTS The..

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Last update 13 May 2019

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