Effects of berberine on the transport of p-gp substrates across caco-2 and l-mdr1 cell monolayers
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: XIN, Huawen (Wuhan General Hospital, Wuhan, China)
- Co-author(s): Wu, Xiao-Chun (Wuhan General Hospital, WUHAN, China)
Li, Qing (Wuhan General Hospital, WUHAN, China)
Yu, Ai-Rong (Wuhan General Hospital, WUHAN, China)
AIM To investigate the effects of berberine (BBR) on the transport of P-gp substrates including cyclosporine A (CsA) and digoxin across Caco-2 and L-MDR cell monolayers. METHODS Permeability coefficients and transport rates of digoxin and CsA across Caco-2 and L-MDR1 monolayers were measured in the presence of BBR(50ÂµM-5mM). RESULTS The.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.