Improvement of the triene macrolide immunosuppressant, sirolimus, producing strain streptomyces hygroscopicus fc904
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: CHENG, Yang-rong (Fujian Institute of Microbiology, Fuzhou, China)
- Co-author(s): Huang, Jie (Fujian Institute of Microbiology, FUZHOU, China)
Jin, Dong-wei (Fujian Institute of Microbiology, FUZHOU, China)
Yu, Hui (Fujian Institute of Microbiology, FUZHOU, China)
Objective In an attempt to improve the productivity of sirolimus(SLM) producer Streptomyces hygroscopicus FC904. Method Mutation and screening of the starting culture, S. hygroscopicus FC904 were carried. Thousands of survivors were obtained after repeating mutagenis by UV and chemical mutagenic agents. Higher SLM-producing mutants were selected.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.