Dh334, a beta-carboline anti-cancer drug, inhibits the cdk activity of budding yeast

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: LI, Yan (Institute of Medicinal Biotechnology, Beijing, China)
• Co-author(s): Liang, Feng Shan (Florida State University, TALLAHASSEE, United States of America)
  Wang, Yanchang (Florida State University, TALLAHASSEE, United States of America)
  Si, Shuyi (Institute of Medicinal Biotechnology, BEIJING, China)
  
• Abstract:

  The β-carboline alkaloids present in medicinal plants, such as Peganum harmala and Eurycoma longifolia, have recently drawn attention due to their antitumor activities. Further mechanistic studies indicate that β-carboline derivatives inhibit DNA topoisomerases and interfere with DNA synthesis. Moreover, some β-carboline compounds are..

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