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Improved solubility, dissolution and bioavailability of ibuprofen using solid dispersions with poloxamer 407.

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
  • Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
    Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
    Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
    Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
    Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  • Abstract:

    Aim: To prepare the solid dispersions containing ibuprofen as a poorly water soluble by low temperature melting method in order to improve its solubility, dissolution rate and bioavailability using poloxamer 407 as a meltable hydrophilic polymer carrier

    Methods: Phase solubility behavior of ibuprofen at 25ËšC in various molar solutions of..

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Last update 4 October 2019

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