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Preparation, characterization, and in-vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188.

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
  • Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
    Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
    Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
    Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
    Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  • Abstract:

    Aim: To prepare and characterizeImprove ibuprofen-poloxamer 188 binary solid dispersions to enhance the solubility, in vitro dissolution and oral bioavailability of ibuprofen.

    Methods: Phase solubility behavior of ibuprofen at 25ËšC in various molar solutions of poloxamer 188 in water was observed, their binary solid dispersions at different..

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Last update 4 October 2019

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