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Synthesis and evaluation of physicochemical properties, enzymatic stability and skin permeation and accumulation profiles of a model fatty acid ester prodrug for local topical application

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
  • Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
    Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
    Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
    Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
    Jang, K. Y. (Yeungnam University, GYOUNGSAN, South-Korea)
    Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
    Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  • Abstract:

    Aim: To achieve minimal skin accumulation without systemic absorption of ketorolac stearate

    Methods: A model fatty acid ester prodrug (ester) - ketorolac stearate - was synthesized and evaluated for its solubility, lipophilicity, chemical stability, enzymatic hydrolysis, and skin permeation and accumulation profiles under normal conditions as..

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Last update 4 October 2019

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