Synthesis and evaluation of physicochemical properties, enzymatic stability and skin permeation and accumulation profiles of a model fatty acid ester prodrug for local topical application

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
• Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
  Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
  Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
  Jang, K. Y. (Yeungnam University, GYOUNGSAN, South-Korea)
  Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
  Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  
• Abstract:

  Aim: To achieve minimal skin accumulation without systemic absorption of ketorolac stearate
  
  Methods: A model fatty acid ester prodrug (ester) - ketorolac stearate - was synthesized and evaluated for its solubility, lipophilicity, chemical stability, enzymatic hydrolysis, and skin permeation and accumulation profiles under normal conditions as..

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