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Synthesis and evaluation of physicochemical properties, enzymatic stability and skin permeation and accumulation profiles of a model fatty acid ester prodrug for local topical application
- At: Beijing (China) (2007)
- Type: Poster
- By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
- Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
Jang, K. Y. (Yeungnam University, GYOUNGSAN, South-Korea)
Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea) - Abstract:
Aim: To achieve minimal skin accumulation without systemic absorption of ketorolac stearate
Methods: A model fatty acid ester prodrug (ester) - ketorolac stearate - was synthesized and evaluated for its solubility, lipophilicity, chemical stability, enzymatic hydrolysis, and skin permeation and accumulation profiles under normal conditions as.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 4 October 2019