Evaluation of skin permeation profiles ofketorolac fatty acid esters

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
• Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
  Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
  Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
  Hyun, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
  Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  
• Abstract:

  Aim: To achieve a higher dermal accumulation without systemic absorption of ketorolac and its fatty acid esters (esters) by synthesizing lipophilic fatty acid esters as soft prodrugs of ketorolac.
  
  Methods: Ketorolac decenoate (C10:1), dodecenoate (C12:1) and palmitoleate (C16:1) were synthesized and evaluated for their lipophilicity, enzymatic..

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