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The enhancement effect of surfactants on the penetration of nitrendipine through rat skin

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: KESAVAN, Bhaskar (NDDS Laboratory, Kakatiya University, Warangal, India)
  • Co-author(s): Chinnala, Krishna Mohan (NDDS Laboratory, Kakatiya University, WARANGAL, India)
    Meka, Lingam (NDDS Laboratory, Kakatiya University, WARANGAL, India)
    Vobalaboina, Venkateswarlu (NDDS Laboratory, Kakatiya University, WARANGAL, India)
    Yamsani, Madhusudan Rao (NDDS Laboratory, Kakatiya University, WARANGAL, India)
    Ravichandran, V. (NDDS Laboratory, Kakatiya University, WARANGAL, India)
  • Abstract:

    Nitrendipine, a dihydropyridines calcium antagonist which has a very low solubility in vitro was used as a poorly water-soluble model drug. The percutaneous permeation of nitrendipine was investigated in rat skin after application of a waterâ€'propylene glycol (50:50% v/v) using a diffusion cell technique. The effect of various surfactants such ..

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Last update 4 October 2019

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