Production of the antimalarial drug precursor amorpha-4,11-diene and artemisinic acid in engineered yeast
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: KONG, Jianqiang (Institute of Materia Medica, Beijing, China)
- Co-author(s): Wang, wei (Institute of Materia Medica, BEIJING, China)
Zhu, ping (Institute of Materia Medica, BEIJING, China)
Dai, jungui (Institute of Materia Medica, BEIJING, China)
Two genes encoding amorpha-4,11-diene synthase(ADS) and amorpha-4,11-diene hydroxylase (CYP71AV1 P450)were cloned from Artemisia annua L. The two genes were related to artemisinin biosynthesis. The other two genes encoding the FPP synthase and HMG-CoA reductase were cloned from Saccharomyces cerevisiae. All cloned cDNAs were confirmed by DNA.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.