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Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity and structure-activity relationships

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Presentations + Posters
  • By: HU, Laixing (Institute of Medicinal Biotechnology, Beijing, China)
  • Co-author(s): Li, Zhuo-rong (Institute of Medicinal Biotechnology, Beijing, China)
    Jin, Jie (Institute of Medicinal Biotechnology, Beijing, China)
    Jiang, Jian-dong (Institute of Medicinal Biotechnology, Beijing, China)
    Boykin, David (Georgia State University, Atlanta, United States of America)
  • Abstract:

    We have described the synthesis, antiproliferative activity and SAR of novel heterocyclic ketones by replacing sulfonamide linkage with a carbonyl group in the lead compound 9-Ethyl -N-(3,4,5-trimethoxyphenyl)-carbazole-3-sulfonamide 1. Most of the heterocyclic ketones showed strong cytotoxicities under 1 uM against CEM leukemia cells. The most

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Last update 4 October 2019

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